To statistically analyze the evolution of forced expiratory along time (volume of air blown out in 1 second -FEV 1-) and the forced vital capacity (FVC), mixed linear models were carried out. Quality of life was evaluated in a subgroup, using the Spanish version of the Revised Cystic Fibrosis Quality of Life Questionnaire (CFQ-R). Clinical, microbiological, analytical and spirometric variables were collected. Adult patients from two CF units of tertiary hospitals were included. The prospective, bicentric and descriptive study was carried out within a 3-year follow-up period, with four-month periodicity medical controls. The aim of this study was to analyse whether chronic respiratory filamentous fungal colonization had clinical impact and whether antifungal treatment can change the disease. There are important advances in the management of bacterial infection in patients with cystic fibrosis (CF), but there are many gaps in the field of fungal infections.
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